Açaí (Euterpe oleracea Mart.) Seed Oil Exerts a Cytotoxic Role over Colorectal Cancer Cells: Insights of Annexin A2 Regulation and Molecular Modeling

Açaí, Euterpe oleracea Mart., is a native plant from the Amazonian and rich in several phytochemicals with anti-tumor activities. The aim was to analyze effects of açaí seed oil on colorectal adenocarcinoma (ADC) cells. In vitro analyses were performed CACO-2, HCT-116, HT-29 cell lines. strains treated for 24, 48, 72 h, viability, death, morphology analyzed. Molecular docking evaluate interaction between major compounds Annexin A2. viability assay showed cytotoxic effect Acai induced increased apoptosis CACO-2 HCT-116 cells interfered cycle. Western blotting an expression LC3-B, suggestive autophagy, A2, regulatory protein. confirmed fatty acids suggesting role modulating A2 these cancer Our results suggest potential contribute development active drug known natural product.